Synthesis of 3,3-disubstituted indoline-2-thiones catalysed by an N-heterocyclic carbene.
نویسندگان
چکیده
A catalytic method has been developed for construction of indoline-2-thiones containing an all-carbon quaternary centre at the C-3 position. Successive treatment of α,β-unsaturated aldehydes bearing an isothiocyanato moiety with an in situ generated N-heterocyclic carbene and an appropriate heteroatomic nucleophile provided the 3,3-disubstituted indoline derivatives in moderate to good yields.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 64 شماره
صفحات -
تاریخ انتشار 2014